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KMID : 0620920140460020005
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Experimental & Molecular Medicine
2014 Volume.46 No. 2 p.5 ~ p.0
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Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells
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Lee Young-Ki
Hur Won-Hee
Lee Sung-Won
Hong Sung-Woo
Kim Sung-Woo
Choi Jung-Eun
Yoon Seung-Kew
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Abstract
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14-3-3ζ is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3ζ decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3ζ affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3ζ decreased cell viability and the number of spheres by reducing radioresistance in CSCs after γ-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3ζ after IR. These results suggest that 14-3-3ζ knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs.
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KEYWORD
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14-3-3ζ, apoptosis, cancer stem-like cell, hepatocellular carcinoma, radioresistance
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